It is believed that the reason for more than 50% of all visits to doctors are initially caused by stress. Many health care professionals consider stress as one of the fundamental reasons for illnesses such as the increase in Diabetes patients.
Others have already proven that humans under stress are more vulnerable and not resistant to trivial diseases such as simple flu.
Cortisol — Its Role in Stress, Inflammation, and Indications for Diet Therapy
Cortisol, a glucocorticoid (steroid hormone), is produced from cholesterol in the two adrenal glands located on top of each kidney. It is normally released in response to events and circumstances such as waking up in the morning, exercising, and acute stress. Cortisol’s far-reaching, systemic effects play many roles in the body’s effort to carry out its processes and maintain homeostasis.
Of interest to the dietetics community, cortisol also plays an important role in human nutrition. It regulates energy by selecting the right type and amount of substrate (carbohydrate, fat, or protein) the body needs to meet the physiological demands placed on it. When chronically elevated, cortisol can have deleterious effects on weight, immune function, and chronic disease risk.
Cortisol (along with its partner epinephrine) is best known for its involvement in the “fight-or-flight” response and temporary increase in energy production, at the expense of processes that are not required for immediate survival. The resulting biochemical and hormonal imbalances (ideally) resolve due to a hormonally driven negative feedback loop. The following is a typical example of how the stress response operates as its intended survival mechanism:
Blood Sugar Imbalance and Diabetes
Under stressful conditions, cortisol provides the body with glucose by tapping into protein stores via gluconeogenesis in the liver. This energy can help an individual fight or flee a stressor. However, elevated cortisol over the long term consistently produces glucose, leading to increased blood sugar levels.
Theoretically, this mechanism can increase the risk for type 2 diabetes, although a causative factor is unknown.1 Since a principal function of cortisol is to thwart the effect of insulin—essentially rendering the cells insulin resistant—the body remains in a general insulin-resistant state when cortisol levels are chronically elevated. Over time, the pancreas struggles to keep up with the high demand for insulin, glucose levels in the blood remain high, the cells cannot get the sugar they need, and the cycle continues.
Prime 3
Prime 3 Anti-Oxidant is a full spectrum blend of 200 nutrients which gives you the most powerful antioxidant available. There is no question about it; doctors and scientists worldwide are recognizing that FREE RADICALS are the cause of cellular breakdown that leads to diseases such as Diabetes and premature ageing. So important is the role of antioxidants that medical science is beginning to consider the presence of Diabetes as a sign of probable antioxidant deficiency, in the same way as scurvy is a sign of Vitamin C deficiency.
An antioxidant is a molecule that inhibits the oxidation of other molecules. Oxidation is a chemical reaction that can produce free radicals, leading to chain reactions that may damage cells.
Diabetes and
Oxidative Stress
A number of complications arise as a consequence of macro and microvascular complications that result from diabetes; these deficits have a central role in the tissue-damaging effects of chronic hyperglycemia. Since endothelial cells (as well as renal mesangial and Schwann cells) are unable to limit glucose transport as well as other cells do, they are more vulnerable to the toxic effects of hyperglycemia.
Oxidative stress results from an imbalance between radical- generating and radical-scavenging systems, i.e. increased free radical production or reduced activity of antioxidant defenses or both. Hyperglycemia-induced oxidative stress has also been associated with increased endothelial cellapoptosis in vitro and in vivo. Several studies have shown that diabetes mellitus (types 1 and 2) is accompanied by increased formation of free radicals and decreased antioxidant capacity, leading to oxidative damage of cell components.
Prime 1
Prime 1 is a nutritional supplement containing 7 adaptogens, designed to be taken every day. It is completely natural and safe for everyone – men, women, and children. Balancing Blood Sugar: Cortisol causes the body to convert proteins from the muscles into sugars, which affects blood sugar levels. Some adaptogens help to regulate blood sugar levels and may help with insulin resistance in diabetes. They may also be helpful for low blood sugar or hypoglycemia.
One of Prime 1 ingredients, Eleutherococcus senticosus (Araliaceae) is a very powerful adaptogenic agent. In the present study, the effects of syringin, an active principle of this herb, on plasma glucose levels in streptozotocin-induced diabetic rats (STZ-diabetic rats) were investigated. Thirty minutes after syringin was intravenously injected into fasting STZ-diabetic rats, plasma glucose levels dose-dependently decreased. In normal rats, syringin at the effective dose (1.0 mg/kg) significantly attenuated the increase in plasma glucose caused by an intravenous glucose challenge. Syringin dose-dependently (0.01 to 10.0 μmol/L) stimulated glucose uptake in soleus muscle isolated from STZ-diabetic rats. Syringin treatment of hepatocytes isolated from STZ-diabetic rats enhanced glycogen synthesis. The ability of syringin to enhance glucose utilization and lower plasma glucose level in rats suffering from insulin deficiency suggest that Eleutherococcus is highly useful in the treatment of human diabetes
Methods of treatment of elevated blood sugar
Depending on how they achieve blood sugar reduction, the medication can be divided into several types . Specifically, these are the following mechanisms of action:
– increased insulin level or efficiency
– reducing the absorption of sugar from the digestive system
– increased use of glucose in tissues (head in fat and muscle)
– reducing blood glucose levels by affecting the activity of the liver
– activation of nuclear PPAR receptors
– increasing the level or effectiveness of adiponectin
– other pathways (incretin, endogenous opioids)
– antioxidant effect
There are currently approximately 150 million diabetics in the world, and this figure will double in 2025. It is also pragmatic that there are medicinal plants that are less clinically proven to be anti-diabetic. And, that doctors know relatively little about these herbs. Diabetes cannot be healed yet – once we get diabetes, it just goes on. However, healing herbs (Adaptogens) like Prime 1 and Prime 3 should not be underestimated as a means of preventing, slowing down diabetes, and alleviating its symptoms and consequences.
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